Burn Wound Laboratory

Dr. Benjamin Levi and his laboratory have produced prolific works. Major media have comprised of scientific journals such as Journal of Plastic Reconstructive Surgery, Public Library of Science, Science of Translational Medicine, Developmental Biology, Proceedings of the National Academy of Science, and Journal of Biological Chemistry.

  • PI: Dr. Benjamin Levi


  1. Kubiak, CA, Ranganathan, K, Matusko, N, Jacobson, JA, Wang, SC, Park, PK, Levi, BL. Computed Tomography Evidence of Psoas Muscle Atrophy Without Concomitant Tendon Wasting in Early Sepsis. J. Surg. Res. 2019;234 :210-216. doi: 10.1016/j.jss.2018.09.010. PubMed PMID:30527476 .
  2. Perusina Lanfranca, M, Thompson, JK, Bednar, F, Halbrook, C, Lyssiotis, C, Levi, B, Frankel, TL. Metabolism and epigenetics of pancreatic cancer stem cells. Semin. Cancer Biol. 2018; :. doi: 10.1016/j.semcancer.2018.09.008. PubMed PMID:30273655 .
  3. Loder, SJ, Agarwal, S, Chung, MT, Cholok, D, Hwang, C, Visser, N, Vasquez, K, Sorkin, M, Habbouche, J, Sung, HH, Peterson, J, Fireman, D, Ranganathan, K, Breuler, C, Priest, C, Li, J, Bai, X, Li, S, Cederna, PS, Levi, B. Characterizing the Circulating Cell Populations in Traumatic Heterotopic Ossification. Am. J. Pathol. 2018;188 (11):2464-2473. doi: 10.1016/j.ajpath.2018.07.014. PubMed PMID:30142335 PubMed Central PMC6222270.
  4. Levi, B, Kraft, CT, Shapiro, GD, Trinh, NT, Dore, EC, Jeng, J, Lee, AF, Acton, A, Marino, M, Jette, A, Armstrong, EA, Schneider, JC, Kazis, LE, Ryan, CM. The Associations of Gender With Social Participation of Burn Survivors: A Life Impact Burn Recovery Evaluation Profile Study. J Burn Care Res. 2018;39 (6):915-922. doi: 10.1093/jbcr/iry007. PubMed PMID:29733365 PubMed Central PMC6198731.
  5. Strong, AL, Levi, B. Discussion: Deferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention. Plast. Reconstr. Surg. 2018;141 (3):666-667. doi: 10.1097/PRS.0000000000004186. PubMed PMID:29481397.
  6. Annamalai, RT, Turner, PA, Carson, WF 4th, Levi, B, Kunkel, S, Stegemann, JP. Harnessing macrophage-mediated degradation of gelatin microspheres for spatiotemporal control of BMP2 release. Biomaterials. 2018;161 :216-227. doi: 10.1016/j.biomaterials.2018.01.040. PubMed PMID:29421557 PubMed Central PMC5831261.
  7. Ranganathan, K, Hong, X, Cholok, D, Habbouche, J, Priest, C, Breuler, C, Chung, M, Li, J, Kaura, A, Hsieh, HHS, Butts, J, Ucer, S, Schwartz, E, Buchman, SR, Stegemann, JP, Deng, CX, Levi, B. High-frequency spectral ultrasound imaging (SUSI) visualizes early post-traumatic heterotopic ossification (HO) in a mouse model. Bone. 2018;109 :49-55. doi: 10.1016/j.bone.2018.01.034. PubMed PMID:29412179 PubMed Central PMC5955392.
  8. Qureshi, AT, Dey, D, Sanders, EM, Seavey, JG, Tomasino, AM, Moss, K, Wheatley, B, Cholok, D, Loder, S, Li, J, Levi, B, Davis, TA. Inhibition of Mammalian Target of Rapamycin Signaling with Rapamycin Prevents Trauma-Induced Heterotopic Ossification. Am. J. Pathol. 2017;187 (11):2536-2545. doi: 10.1016/j.ajpath.2017.07.010. PubMed PMID:29029772 PubMed Central PMC5809339.
  9. Cholok, D, Chung, MT, Ranganathan, K, Ucer, S, Day, D, Davis, TA, Mishina, Y, Levi, B. Heterotopic ossification and the elucidation of pathologic differentiation. Bone. 2018;109 :12-21. doi: 10.1016/j.bone.2017.09.019. PubMed PMID:28987285 .
  10. Strong, AL, Agarwal, S, Cederna, PS, Levi, B. Peripheral Neuropathy and Nerve Compression Syndromes in Burns. Clin Plast Surg. 2017;44 (4):793-803. doi: 10.1016/j.cps.2017.05.010. PubMed PMID:28888304 PubMed Central PMC5674779.
  11. Agarwal, S, Sorkin, M, Levi, B. Heterotopic Ossification and Hypertrophic Scars. Clin Plast Surg. 2017;44 (4):749-755. doi: 10.1016/j.cps.2017.05.006. PubMed PMID:28888300 PubMed Central PMC5658026.
  12. Agarwal, S, Loder, SJ, Breuler, C, Li, J, Cholok, D, Brownley, C, Peterson, J, Hsieh, HH, Drake, J, Ranganathan, K, Niknafs, YS, Xiao, W, Li, S, Kumar, R, Tompkins, R, Longaker, MT, Davis, TA, Yu, PB, Mishina, Y, Levi, B. Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification. Mol. Ther. 2017;25 (8):1974-1987. doi: 10.1016/j.ymthe.2017.01.008. PubMed PMID:28716575 PubMed Central PMC5542633.
  13. Dey, D, Wheatley, BM, Cholok, D, Agarwal, S, Yu, PB, Levi, B, Davis, TA. The traumatic bone: trauma-induced heterotopic ossification. Transl Res. 2017;186 :95-111. doi: 10.1016/j.trsl.2017.06.004. PubMed PMID:28668522 .
  14. Levi, B. “AMP”(K)ed up recovery from ischemia-reperfusion injury. Sci Transl Med. 2017;9 (395):. doi: 10.1126/scitranslmed.aan6194. PubMed PMID:28637927 .
  15. Friedstat, J, Brown, DA, Levi, B. Chemical, Electrical, and Radiation Injuries. Clin Plast Surg. 2017;44 (3):657-669. doi: 10.1016/j.cps.2017.02.021. PubMed PMID:28576255 PubMed Central PMC5488710.
  16. Strong, AL, Neumeister, MW, Levi, B. Stem Cells and Tissue Engineering: Regeneration of the Skin and Its Contents. Clin Plast Surg. 2017;44 (3):635-650. doi: 10.1016/j.cps.2017.02.020. PubMed PMID:28576253 PubMed Central PMC5513194.
  17. Griggs, C, Goverman, J, Bittner, EA, Levi, B. Sedation and Pain Management in Burn Patients. Clin Plast Surg. 2017;44 (3):535-540. doi: 10.1016/j.cps.2017.02.026. PubMed PMID:28576242 PubMed Central PMC5642992.
  18. Sorkin, M, Agarwal, S, Ranganathan, K, Loder, S, Cholok, D, Fireman, D, Li, J, Li, S, Zhao, B, Mishina, Y, Cederna, P, Levi, B. Hair follicle specific ACVR1/ALK2 critically affects skin morphogenesis and attenuates wound healing. Wound Repair Regen. 2017;25 (3):521-525. doi: 10.1111/wrr.12549. PubMed PMID:28513105 PubMed Central PMC5568946.
  19. Grafe, I, Alexander, S, Peterson, JR, Snider, TN, Levi, B, Lee, B, Mishina, Y. TGF-β Family Signaling in Mesenchymal Differentiation. Cold Spring Harb Perspect Biol. 2018;10 (5):. doi: 10.1101/cshperspect.a022202. PubMed PMID:28507020 .
  20. Levi, B. “TrkA”cking why “no pain, no gain” is the rule for bone formation. Sci Transl Med. 2017;9 (389):. doi: 10.1126/scitranslmed.aan3780. PubMed PMID:28490668 .
  21. Sung Hsieh, HH, Chung, MT, Allen, RM, Ranganathan, K, Habbouche, J, Cholok, D, Butts, J, Kaura, A, Tiruvannamalai-Annamalai, R, Breuler, C, Priest, C, Loder, SJ, Li, J, Li, S, Stegemann, J, Kunkel, SL, Levi, B. Evaluation of Salivary Cytokines for Diagnosis of both Trauma-Induced and Genetic Heterotopic Ossification. Front Endocrinol (Lausanne). 2017;8 :74. doi: 10.3389/fendo.2017.00074. PubMed PMID:28484423 PubMed Central PMC5401868.
  22. Levi, B, Ricci, JA, Donelan, MB. Vermillion Reconstruction With Anal Verge Transitional Epithelium: Turning Things Upside Down. J Burn Care Res. 2018;39 (2):218-223. doi: 10.1097/BCR.0000000000000569. PubMed PMID:28481757 .
  23. Nguyen, V, Meyers, CA, Yan, N, Agarwal, S, Levi, B, James, AW. BMP-2-induced bone formation and neural inflammation. J Orthop. 2017;14 (2):252-256. doi: 10.1016/j.jor.2017.03.003. PubMed PMID:28367006 PubMed Central PMC5362134.
  24. Ko, JH, Levi, B. Optimizing the Treatment of Burn Injuries of the Upper Extremity. Hand Clin. 2017;33 (2):xiii. doi: 10.1016/j.hcl.2017.02.001. PubMed PMID:28363305 .
  25. Agarwal, S, Loder, S, Levi, B. Heterotopic Ossification Following Upper Extremity Injury. Hand Clin. 2017;33 (2):363-373. doi: 10.1016/j.hcl.2016.12.013. PubMed PMID:28363301 PubMed Central PMC5394800.
  26. Sorkin, M, Cholok, D, Levi, B. Scar Management of the Burned Hand. Hand Clin. 2017;33 (2):305-315. doi: 10.1016/j.hcl.2016.12.009. PubMed PMID:28363297 PubMed Central PMC5436973.
  27. Levi, B. Macrophages take rheumatoid arthritis up a “Notch”. Sci Transl Med. 2017;9 (383):. doi: 10.1126/scitranslmed.aan3022. PubMed PMID:28356509 .
  28. Cocks, M, Mohan, A, Meyers, CA, Ding, C, Levi, B, McCarthy, E, James, AW. Vascular patterning in human heterotopic ossification. Hum. Pathol. 2017;63 :165-170. doi: 10.1016/j.humpath.2017.03.005. PubMed PMID:28315426 PubMed Central PMC5529164.