Burn Wound Laboratory

Dr. Benjamin Levi and his laboratory have produced prolific works. Major media have comprised of scientific journals such as Journal of Plastic Reconstructive Surgery, Public Library of Science, Science of Translational Medicine, Developmental Biology, Proceedings of the National Academy of Science, and Journal of Biological Chemistry.

  • PI: Dr. Benjamin Levi

Publications

Selected Publications
  1. Annamalai, RT, Turner, PA, Carson, WF 4th, Levi, B, Kunkel, S, Stegemann, JP. Harnessing macrophage-mediated degradation of gelatin microspheres for spatiotemporal control of BMP2 release. Biomaterials. 2018;161 :216-227. doi: 10.1016/j.biomaterials.2018.01.040. PubMed PMID:29421557 .
  2. Ranganathan, K, Hong, X, Cholok, D, Habbouche, J, Priest, C, Breuler, C, Chung, M, Li, J, Kaura, A, Hsieh, HHS, Butts, J, Ucer, S, Schwartz, E, Buchman, SR, Stegemann, JP, Deng, CX, Levi, B. High-frequency spectral ultrasound imaging (SUSI) visualizes early post-traumatic heterotopic ossification (HO) in a mouse model. Bone. 2018; :. doi: 10.1016/j.bone.2018.01.034. PubMed PMID:29412179 .
  3. Qureshi, AT, Dey, D, Sanders, EM, Seavey, JG, Tomasino, AM, Moss, K, Wheatley, B, Cholok, D, Loder, S, Li, J, Levi, B, Davis, TA. Inhibition of Mammalian Target of Rapamycin Signaling with Rapamycin Prevents Trauma-Induced Heterotopic Ossification. Am. J. Pathol. 2017;187 (11):2536-2545. doi: 10.1016/j.ajpath.2017.07.010. PubMed PMID:29029772 .
  4. Cholok, D, Chung, MT, Ranganathan, K, Ucer, S, Day, D, Davis, TA, Mishina, Y, Levi, B. Heterotopic ossification and the elucidation of pathologic differentiation. Bone. 2017; :. doi: 10.1016/j.bone.2017.09.019. PubMed PMID:28987285 .
  5. Strong, AL, Agarwal, S, Cederna, PS, Levi, B. Peripheral Neuropathy and Nerve Compression Syndromes in Burns. Clin Plast Surg. 2017;44 (4):793-803. doi: 10.1016/j.cps.2017.05.010. PubMed PMID:28888304 PubMed Central PMC5674779.
  6. Agarwal, S, Sorkin, M, Levi, B. Heterotopic Ossification and Hypertrophic Scars. Clin Plast Surg. 2017;44 (4):749-755. doi: 10.1016/j.cps.2017.05.006. PubMed PMID:28888300 PubMed Central PMC5658026.
  7. Agarwal, S, Loder, SJ, Breuler, C, Li, J, Cholok, D, Brownley, C, Peterson, J, Hsieh, HH, Drake, J, Ranganathan, K, Niknafs, YS, Xiao, W, Li, S, Kumar, R, Tompkins, R, Longaker, MT, Davis, TA, Yu, PB, Mishina, Y, Levi, B. Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification. Mol. Ther. 2017;25 (8):1974-1987. doi: 10.1016/j.ymthe.2017.01.008. PubMed PMID:28716575 PubMed Central PMC5542633.
  8. Dey, D, Wheatley, BM, Cholok, D, Agarwal, S, Yu, PB, Levi, B, Davis, TA. The traumatic bone: trauma-induced heterotopic ossification. Transl Res. 2017;186 :95-111. doi: 10.1016/j.trsl.2017.06.004. PubMed PMID:28668522 .
  9. Levi, B. "AMP"(K)ed up recovery from ischemia-reperfusion injury. Sci Transl Med. 2017;9 (395):. doi: 10.1126/scitranslmed.aan6194. PubMed PMID:28637927 .
  10. Friedstat, J, Brown, DA, Levi, B. Chemical, Electrical, and Radiation Injuries. Clin Plast Surg. 2017;44 (3):657-669. doi: 10.1016/j.cps.2017.02.021. PubMed PMID:28576255 PubMed Central PMC5488710.
  11. Strong, AL, Neumeister, MW, Levi, B. Stem Cells and Tissue Engineering: Regeneration of the Skin and Its Contents. Clin Plast Surg. 2017;44 (3):635-650. doi: 10.1016/j.cps.2017.02.020. PubMed PMID:28576253 PubMed Central PMC5513194.
  12. Griggs, C, Goverman, J, Bittner, EA, Levi, B. Sedation and Pain Management in Burn Patients. Clin Plast Surg. 2017;44 (3):535-540. doi: 10.1016/j.cps.2017.02.026. PubMed PMID:28576242 PubMed Central PMC5642992.
  13. Sorkin, M, Agarwal, S, Ranganathan, K, Loder, S, Cholok, D, Fireman, D, Li, J, Li, S, Zhao, B, Mishina, Y, Cederna, P, Levi, B. Hair follicle specific ACVR1/ALK2 critically affects skin morphogenesis and attenuates wound healing. Wound Repair Regen. 2017;25 (3):521-525. doi: 10.1111/wrr.12549. PubMed PMID:28513105 PubMed Central PMC5568946.
  14. Grafe, I, Alexander, S, Peterson, JR, Snider, TN, Levi, B, Lee, B, Mishina, Y. TGF-β Family Signaling in Mesenchymal Differentiation. Cold Spring Harb Perspect Biol. 2017; :. doi: 10.1101/cshperspect.a022202. PubMed PMID:28507020 .
  15. Levi, B. "TrkA"cking why "no pain, no gain" is the rule for bone formation. Sci Transl Med. 2017;9 (389):. doi: 10.1126/scitranslmed.aan3780. PubMed PMID:28490668 .
  16. Sung Hsieh, HH, Chung, MT, Allen, RM, Ranganathan, K, Habbouche, J, Cholok, D, Butts, J, Kaura, A, Tiruvannamalai-Annamalai, R, Breuler, C, Priest, C, Loder, SJ, Li, J, Li, S, Stegemann, J, Kunkel, SL, Levi, B. Evaluation of Salivary Cytokines for Diagnosis of both Trauma-Induced and Genetic Heterotopic Ossification. Front Endocrinol (Lausanne). 2017;8 :74. doi: 10.3389/fendo.2017.00074. PubMed PMID:28484423 PubMed Central PMC5401868.
  17. Levi, B, Ricci, JA, Donelan, MB. Vermillion Reconstruction With Anal Verge Transitional Epithelium: Turning Things Upside Down. J Burn Care Res. 2017; :. doi: 10.1097/BCR.0000000000000569. PubMed PMID:28481757 .
  18. Nguyen, V, Meyers, CA, Yan, N, Agarwal, S, Levi, B, James, AW. BMP-2-induced bone formation and neural inflammation. J Orthop. 2017;14 (2):252-256. doi: 10.1016/j.jor.2017.03.003. PubMed PMID:28367006 PubMed Central PMC5362134.
  19. Ko, JH, Levi, B. Optimizing the Treatment of Burn Injuries of the Upper Extremity. Hand Clin. 2017;33 (2):xiii. doi: 10.1016/j.hcl.2017.02.001. PubMed PMID:28363305 .
  20. Agarwal, S, Loder, S, Levi, B. Heterotopic Ossification Following Upper Extremity Injury. Hand Clin. 2017;33 (2):363-373. doi: 10.1016/j.hcl.2016.12.013. PubMed PMID:28363301 PubMed Central PMC5394800.
  21. Sorkin, M, Cholok, D, Levi, B. Scar Management of the Burned Hand. Hand Clin. 2017;33 (2):305-315. doi: 10.1016/j.hcl.2016.12.009. PubMed PMID:28363297 PubMed Central PMC5436973.
  22. Levi, B. Macrophages take rheumatoid arthritis up a "Notch". Sci Transl Med. 2017;9 (383):. doi: 10.1126/scitranslmed.aan3022. PubMed PMID:28356509 .
  23. Cocks, M, Mohan, A, Meyers, CA, Ding, C, Levi, B, McCarthy, E, James, AW. Vascular patterning in human heterotopic ossification. Hum. Pathol. 2017;63 :165-170. doi: 10.1016/j.humpath.2017.03.005. PubMed PMID:28315426 PubMed Central PMC5529164.
  24. Agarwal, S, Loder, S, Cholok, D, Li, J, Breuler, C, Drake, J, Brownley, C, Peterson, J, Li, S, Levi, B. Surgical Excision of Heterotopic Ossification Leads to Re-Emergence of Mesenchymal Stem Cell Populations Responsible for Recurrence. Stem Cells Transl Med. 2017;6 (3):799-806. doi: 10.5966/sctm.2015-0365. PubMed PMID:28297577 PubMed Central PMC5442786.
  25. Rinkinen, J, Levi, B, Cederna, PS. Discussion: Homeotic and Embryonic Gene Expression in Breast Adipose Tissue and in Adipose Tissues Used as Donor Sites in Plastic Surgery. Plast. Reconstr. Surg. 2017;139 (3):693e-694e. doi: 10.1097/PRS.0000000000003071. PubMed PMID:28234839 .
  26. Levi, B. Perceived health status in a comparative perspective: Methodological limitations and policy implications for Israel. Isr J Health Policy Res. 2017;6 :2. doi: 10.1186/s13584-016-0128-x. PubMed PMID:28101328 PubMed Central PMC5237327.
  27. Agarwal, S, Lloyd, WR, Loder, SJ, Chung, MT, Hwang, C, Morris, MD, Levi, B. Combined reflectance and Raman spectroscopy to assess degree of in vivo angiogenesis after tissue injury. J. Surg. Res. 2017;209 :174-177. doi: 10.1016/j.jss.2016.09.017. PubMed PMID:28032556 PubMed Central PMC5536340.
  28. Agarwal, S, Cholok, D, Loder, S, Li, J, Breuler, C, Chung, MT, Sung, HH, Ranganathan, K, Habbouche, J, Drake, J, Peterson, J, Priest, C, Li, S, Mishina, Y, Levi, B. mTOR inhibition and BMP signaling act synergistically to reduce muscle fibrosis and improve myofiber regeneration. JCI Insight. 2016;1 (20):e89805. doi: 10.1172/jci.insight.89805. PubMed PMID:27942591 PubMed Central PMC5135269.
  29. Ranganathan, K, Agarwal, S, Cholok, D, Loder, S, Li, J, Sung Hsieh, HH, Wang, SC, Buchman, SR, Levi, B. The role of the adaptive immune system in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation. J. Surg. Res. 2016;206 (1):53-61. doi: 10.1016/j.jss.2016.04.040. PubMed PMID:27916375 PubMed Central PMC5532013.
  30. Agarwal, S, Loder, SJ, Cholok, D, Peterson, J, Li, J, Breuler, C, Cameron Brownley, R, Hsin Sung, H, Chung, MT, Kamiya, N, Li, S, Zhao, B, Kaartinen, V, Davis, TA, Qureshi, AT, Schipani, E, Mishina, Y, Levi, B. Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon. Stem Cells. 2017;35 (3):705-710. doi: 10.1002/stem.2515. PubMed PMID:27862618 PubMed Central PMC5529170.
See More on PubMed
Textbook
  1. Editor, Michigan Manual of Plastic Surgery, Second Edition. (Lippincott Williams and Wilkins, New York, in progress).
  1. Section Editor, “Burns.” Michigan Manual of Plastic Surgery, Second Edition.  (Lippincott Williams and Wilkins, New York, in progress).
  1. Section Editor, “Trunk and Lower Extremity Reconstruction” Michigan Manual of Plastic Surgery, Second Edition.  (Lippincott Williams and Wilkins, New York, in progress).
  1. Section Editor, “Fundamentals and Principles.” Michigan Manual of Plastic Surgery, Second Edition.  (Lippincott Williams and Wilkins, New York, in progress)
Non Peer Reviewed
  1. Chapter: Levi B, Wong VC and Sheridan R.  Burn Surgery and Critical Care. Massachussetts General Hospital Critical Care Handbook, Ed. 2.  In Press.
  2. Chapter: Levi B, Hemilla M, and Wang SC.  Burn Surgery.  Greenfield’s Surgery Ed 8.  In Press.
  3. Chapter: Donneys A, Nelson N, Ahsan S, Peterson JR, Morris MD, Esmonde-White F, Buchman SR, Wang SC, and Levi B.  “Advancements in Cortical Bone Imaging”Trabecular and Cortical Bone: Morphology, Biomechanics and Clinical Implications. Ed Varsha Subramanium and Manish Bhatnagar.  New York: Nova Biomedical, 2014. 137-162.
  4. Review: JP Glotzbach, VW Wong, Levi B, MT Longaker, GC Gurtner.  Delivery
  5. Review: Strong AL, Ranganathan K, Chang ET, Sorkin M, Agarwal  S and Levi B. Burns: Epidemiology, Management and Impact on Muscle & Joint Function.  Accepted for publication 12/2013.
  6. Review: Glotzbach JG*, Levi B*, Wong V, Longaker MT and Gurtner GC. The Basic Science of Vascular Biology: Implications for the Practicing Surgeon. Plast. Reconstr. Surg. 126(5):1528-38, 2010. PMID: 21042110.