Dexter Ann Arbor Run 2018

Dexter-Ann Arbor Run, 2018

BWR Lab had a successful 5k competition coming in 1st place amongst the team 5K open competition. The lab had also impressive top ten finishes within individual age brackets as well (as below)
BWR Lab Team named “Feel the Burn” – 1st place in Team 5k OPEN race
Individual results:
Dr. Levi, 1st in age bracket
Noelle Visser, 3rd in age bracket
Karen Kessel, 3rd in age bracket
Charles Hwang – 8th in age bracket
Dr. Levi – 14th overall

First Annual Fibrodysplasia Ossificans Progressiva (FOP) & Traumatic Heterotopic Ossification (HO) Symposium

Post-Doctoral Fellow Position Available Immediately

University of Michigan

Burn/Wound and Regenerative Medicine Laboratory

Benjamin Levi, MD

Close Collaborators at UM:

  • Yuji Mishina, PhD : School of Dentistry

  • Ernestina Schipani MD, PhD: Department of Cell and Molecular Biology

  • Paul Cederna MD: Department of Biomedical Engineering


Our NIH/DOD funded laboratory focuses primarily on the role of trauma on stem cell migration and differentiation. Specifically, we focus on bone healing both in the craniofacial and appendicular skeleton. Additionally, we focus on the process of heterotopic ossification after trauma. Heterotopic ossification (HO) leads to bone deposition in extra-skeletal sites severely restricting range of motion, limiting prosthetic use and causing chronic pain and wounds. HO occurs in over 20% of primary hip replacements, extremity traumas, amputations, large total body surface area burns, traumatic brain injuries, spinal cord injuries and pressure ulcers, and over 65% of repeat hip replacements and blast injuries. Our group focuses on early detection and prevention through targeted mechanism-based therapeutic approaches.

Recent Publications

  1. Peterson JR, De La Rosa S, Oluwatobi E, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SW and Levi B. Treatment of Heterotopic Ossification through Remote ATP Hydrolysis. Sci Transl Med. 2014 Sep 24;6(255). PMID: 2525367.
  2. Peterson JR, Eboda O, Agarwal S, Ranganathan K, Buchman SR, Lee M, Wang SC, Mishina Y and Levi B. Targeting of ALK2, a receptor for BMPs, using the Cre/lox system to enhance osseous regeneration by adipose derived stem cells. Stem Cells Transl Med. 2014 Sep 17. pii: sctm.2014-0082. PMID: 25232183.
  3. Peterson JR, Eboda O, Brownley RC, Cilwa KE, Pratt LE, De La Rosa S, Agarwal S, Buchman SR, Cederna PS, Morris MD, Wang SC and Levi B. Effects of Aging on Osteogenic Response and Heterotopic Ossification Following Burn Injury in Mice. Stem Cells Development. 2014 Aug 14. PMID: 25122460.
  4. Agarwal S, Loder SJ, Brownley C, Eboda O, Peterson JR, Hayano S, Wu B, ZhaB, Kaartinen V, Wong VC, Mishina Y, Levi B. BMP signaling mediated by constitutively active Activitype 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints. Dev Biol. 2015 Feb 23.
  5. Agarwal S, Loder S, Brownley C, Cholok D, Mangiavini L, Li J, Breuler C, Sung HH, Li S, Ranganathan K, Peterson J, Tompkins R, Herndon D, Xiao W, Jumlongras D, Olsen BR, Davis TA, Mishina Y, Schipani E, Levi B. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2015 Dec 31. pii: 201515397. [Epub ahead of print]. PMID: 26721400.

Contact if interested: [email protected]

3rd Drug Development Forum a Tremendous Success

On October 13-14, the world’s leading experts in FOP gathered in Sardinia, Italy for the 2017 Drug Development Forum (DDF). The 2017 DDF attracted researchers from 21 different countries to discuss their latest research findings, to solve key issues in FOP drug development, and to strengthen ties among a growing network of collaborating labs across the world… read full article here.

The American Journal of Pathology’s Facebook page

The American Journal of Pathology’s Facebook page and on Twitter @AJPathology.  We posted it earlier with the accompanying press release, but we wanted to inform our readers that, as an Editor’s Choice article, the full text is now freely available to everyone.

Dr. Levi Treats Nautical Trauma