Pathway
Some implicated molecules after burn injury induced inflammation include BMP-2, BMP-4, and TGF-beta. Uncovered agents like these pose potential candidates for more efficient, targeted interventions. Patients with HO often require surgical excision, and currently trialed drugs such as NSAIDs or bisphosphonates are not tolerated by all patients, have limited efficacy, and do not target the mechanism responsible for HO. With a dedicated team-based approach, the BWR laboratory is elucidating the mechanistic pathways involved in HO and developing novel diagnostic and therapeutic strategies to improve the current treatment paradigm of this destructive process.